/People

Sharon Shacham

Investor

PhD, MBA | Managing Partner at E44 Ventures

Tel Aviv, Israel

Writes $1M – $5M checks · typically $2M

Find your path to Sharon

213 people in our graph share verified history with Sharon — schools, employers, funds. One of them is your warm intro.

Ittai HarelunlockedSharon: together at Protai (2022–2026)
Sharon: together at Sporos Bioventures
×5Sharon: together at E44 Ventures
×2Sharon: together at Gigablue

About

Drug inventor and entrepreneur who founded two NASDAQ companies (KPTI, EPIX) and raised over $750M. She serves as an active board member for multiple biotech ventures and holds a PhD in Computational Biophysics & Biochemistry and an MBA.

Experience

  1. E44 VenturesCo-Founder and Managing Directorcurrent2022 — presentTel Aviv, Israel
  2. phelasAdvisory Boardcurrent2023 — present
  3. GigablueBoard Observercurrent2023 — present
  4. CarbonadeBoard Observercurrent2023 — present
  5. AgriPassBoard Membercurrent2023 — present
  6. Karyopharm Therapeutics Inc.Foundercurrent2009 — present
  7. Karyopharm Therapeutics Inc.Scientific Advisory Board Membercurrent2009 — present
  8. Karyopharm Therapeutics Inc.Chief Scientific Officer2021 — 2022Newton, Massachusetts, United States
  9. Karyopharm Therapeutics Inc.President and CSO2011 — 2021Newton, Massachusetts, United States
  10. Karyopharm Therapeutics Inc.CEO and President2009 — 2011
  11. Sporos BioventuresScientific and Clinical Advisorcurrent2021 — present
  12. Acrivon Therapeutics, Inc.Board Membercurrent2021 — present
  13. Merlin HealthBoard Membercurrent2021 — present
  14. ProtaiScientific Advisorcurrent2022 — present
  15. Polaroid TherapeuticsCo-Founder2021 — 2022Zurich, Switzerland
  16. EPIX PharmaceuticalsSVP Drug Development2000 — 2009
  17. Predix PharmaceuticalsDirector, Algorithm and Software Development2000 — 2003

Investments

Investor

Phelas

Per curated public sources.

What founders say

No founder feedback on Sharon Shacham yet.

Colleagues at E44 Ventures

Frequently asked questions

Who is Sharon Shacham?
Drug inventor and entrepreneur who founded two NASDAQ companies (KPTI, EPIX) and raised over $750M. She serves as an active board member for multiple biotech ventures and holds a PhD in Computational Biophysics & Biochemistry and an MBA.
Where does Sharon Shacham work?
Sharon Shacham is PhD, MBA | Managing Partner at E44 Ventures.
What check size does Sharon Shacham write?
Sharon Shacham typically writes checks of $1M – $5M.
What companies has Sharon Shacham invested in?
Investments tracked here include Phelas.
Where did Sharon Shacham go to school?
Sharon Shacham studied at Tel Aviv University (PhD, Biochemistry and Computational Biophysics); Tel Aviv University (MBA, Information Systems).

Same school

Shared employers