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Third Security, LLC

Family office

Radford · Growth · 7 people tracked

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Investment thesis

Third Security manages a portfolio of operating biotechnology companies while also functioning as a family office. The firm collaborates closely with its portfolio companies to accelerate innovation and growth, with a focus on applying biology to solve problems around the world.

Source: firm website, verified Aug 3, 2026.

Stage
Growth
HQ
Radford, Virginia, US
Instruments
Equity
Founded
1999
Tracked investments
4
IPOs
1
Acquisitions
1

Team · 7 people

from the firm's website & public directories
Julian P. Kirk· Chief Executive Officerin

With Third Security since its inception and appointed CEO in November 2020, he oversees internal operations and works with portfolio companies, holding board and officer roles at GreenVenus and several Oxitec entities. He graduated as an Echols Scholar from the University of Virginia.

Randal J. Kirk· Executive Chairman

Founder and Executive Chairman of Third Security, having served as CEO from inception until November 2020. He founded New River Pharmaceuticals and has held board and executive roles at numerous public biotech companies including Precigen (formerly Intrexon), Halozyme, and ZIOPHARM. He holds a B.A. from Radford University and a J.D. from the University of Virginia.

Clifton R. Herndon· II, Managing Director and Controller

CFO of Third Security since its inception, focusing on audit, internal control, financial operations, and technical accounting for the firm and its portfolio companies. He previously worked at Long-Airdox Company and Ernst & Young, and holds a B.B.A. in Accounting from Marshall University.

Doit L. Koppler· II, Managing Director and Treasurer

Chief Investment Officer leading Third Security's investment and portfolio management functions, including asset allocation, due diligence, deal structuring, and treasury management. He joined in 2001 and previously worked at General Injectables & Vaccines and Ernst & Young. He holds a B.S. in Accounting from Salem University.

Theodore J. Fisher· Senior Managing Director
April D. Jones· Vice President, Legal and Compliancein

Joined Third Security in 2010 and serves as Chief Compliance Officer, overseeing regulatory compliance, legal operations, corporate governance, and document retention. She previously worked at Precigen (formerly Intrexon) and holds a B.A. in History from Virginia Tech.

Jeffrey Perez· Chief Legal Officerin

Chief Legal Officer of Third Security, providing legal, intellectual property, corporate governance, and strategic counsel to the firm and its portfolio companies. He previously led IP affairs at Precigen and practiced IP law at Hunton & Williams. He holds a B.S. from Cornell and a J.D. from George Mason University.

What they invest in

from 4 of 4 portfolio companies

Biotech ×4AgTech ×3FoodTech ×2AI & Machine Learning ×1Healthtech ×1Medical Devices ×1

HQs:United States×1

Investments · 4 tracked

founders shown can be your intro path
Precigenprecigen.comin𝕏NASDAQ: PGEN

Precigen is a biopharmaceutical company developing gene and cell therapies, including PAPZIMEOS (zopapogene imadenovec-drba), an FDA-approved immunotherapy for adults with recurrent respiratory papillomatosis.

BiotechHealthtechMedical DevicesGermantown, US

Thomas D. Reed(Executive Officer)Thomas R. Kasser(Executive Officer)Suma M. Krishnan(Executive Officer)Robert F. Walsh, III(Executive Officer)Helen Sabzevari, PhD(President and CEO)Timothy Kasbe(Executive Officer)

Co-investorsThird Point Ventures

GreenVenusgreenvenus.comin

GreenVenus develops improved crop varieties including leafy greens, grapes, berries, avocados, beans, and lentils using breeding technologies focused on traits such as longer shelf-life, improved flavor, and higher yields.

AgTechBiotechFoodTech

Alana D. Kirk(President and CEO)in

Okanagan Specialty Fruitsosfruits.comin𝕏

Okanagan Specialty Fruits uses biotechnology to develop fruit varieties aimed at more efficient and sustainable food production.

AgTechBiotechFoodTech

Neal Carter(Founder and CEO)in

Oxitecoxitec.comacquired by Precigen

Flyttr operates a biosecurity platform that develops and deploys countermeasures against pest threats, combining autonomous pest monitoring systems, AI-powered decision-support, and biological interventions such as engineered Aedes aegypti and Wolbachia.

AgTechAI & Machine LearningBiotech

Co-investorsH20 Venture PartnersRockley Group

Exits · 2

1 IPOs · 1 acquisitions

PrecigenNASDAQ: PGENOxitecacq. by Precigen

Portfolio news

latest coverage across their companies

Frequently asked questions

What stage does Third Security, LLC invest at?
Third Security, LLC invests at the Growth stage.
What sectors does Third Security, LLC focus on?
Third Security, LLC focuses on Biotech.
Where is Third Security, LLC located?
Third Security, LLC is headquartered in Radford, US.
Who does Third Security, LLC co-invest with?
Third Security, LLC most often shares deals with H20 Venture Partners, Rockley Group, Third Point Ventures, among 3 tracked co-investors.

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