Y Combinator Spring 2026 (X26) Companies

Asendia clones top recruiters using AI to screen job candidates at scale for staffing agencies and enterprise hiring teams. The platform automates candidate screening and qualification, delivering ranked shortlists within hours rather than weeks.

1 investor

Aseon Labs builds autonomous robotic service stations that provide charging, cleaning, and inspection for self-driving vehicles deployed in the field. The company serves operators of autonomous vehicle fleets.

2 investors

Aster develops autonomous research systems designed to accelerate scientific discovery by automating open-ended research tasks. The company aims to compress decades of research timelines into hours through AI-driven experimentation.

1 investor

Astraea provides clinical trial automation software for pharmaceutical sponsors that uses AI to automate post-protocol tasks including statistical analysis plans, case report forms, datasets, regulatory documentation, and FDA submissions. The platform is deployed within the sponsor's own environment to maintain data security and compliance across oncology, rare disease, and medical devices.

1 investor

Atrisa provides an AI-powered assistant for analog circuit design, enabling engineers to create designs, debug circuits, and run simulations through natural language interaction.

1 investor

Autostep is an AI-powered operations intelligence platform that automatically discovers repetitive tasks and inefficiencies across a company's workflows, prices them in real dollars, and generates custom agents and process improvements deployed into existing tools. It serves enterprise teams seeking to optimize operations without manual consulting or interviews.

1 investor

Auxos provides AI-powered customer research and survey tools that use AI clones grounded in real respondent interviews to help companies test hypotheses, understand customer segments, and validate messages. The platform serves product teams, marketers, and strategists looking to conduct rapid customer research and competitive testing.

1 investor

Avea Robotics provides ultra-low latency teleoperation software for robotics companies to remotely control, monitor, and collect data from robots. The platform, called Sentinel, enables reliable robot operation, data collection for AI training, and supervised autonomy across multiple deployments.

1 investor

BentoLabs AI builds monitoring and learning infrastructure for long-running AI agents, detecting silent regressions and converting resolved failures into durable agent intelligence. The platform serves teams deploying agentic systems in production.

1 investor

BioStack provides a platform for bioinformatics and experimental science that integrates biological insights with computational technology. The platform serves researchers and scientists working in modern biology and life sciences research.

3 investors

Bloom is an AI-powered brand management system that unifies brand assets from multiple sources and generates on-brand content including images, videos, and copy. It serves creative teams, agencies, and businesses that need to maintain consistent branding across channels and integrates via API and MCP protocols.

1 investor

Callab provides AI voice agents for enterprise contact centers that integrate with existing PBX, SBC, and telephony infrastructure via SIP without migration. The platform handles inbound support, outbound campaigns, appointment scheduling, and lead qualification with real-time human supervision, call recording, transcription, CRM integration, and compliance controls.

2 investors

CentralComs develops AI agents that integrate with property management software to monitor maintenance requests, manage open work orders, and notify stakeholders throughout the resolution process.

1 investor

CharacterQuilt provides AI-powered campaign management that automates audience data collection, creative asset generation, and deployment across existing marketing tools like HubSpot, Marketo, and LinkedIn Ads. The platform serves marketing teams that need to increase campaign throughput without adding headcount or learning new platforms.

3 investors

Chert provides an API platform that makes iMessage programmable at scale for business workflows. It enables teams to send, receive, route, and monitor iMessage conversations with features like native blue-bubble messaging, typing indicators, file attachments, and fallback to SMS/RCS, serving go-to-market and customer-facing teams.

1 investor

Chronicle uses production data to generate test scenarios and evaluate AI agents before deployment, helping businesses verify agent readiness and reduce critical failures. The platform serves teams building and deploying AI agents.

1 investor

Cignara provides AI agents for voice and chat-based customer support that handle transactions, take actions, and provide real-time assistance to enterprise customers across retail, banking, telecom, healthcare, and other industries.

1 investor

Clara is an AI-powered primary care practice that pairs licensed clinicians with artificial intelligence to deliver personalized, proactive healthcare through virtual visits and secure messaging. The company serves patients seeking primary care and is based in San Francisco.

1 investor

Clawvisor provides access control and governance infrastructure for AI agents in production, enabling task-based verification, scoping, and logging while maintaining agent performance. The platform is built for teams running agents that require security controls and audit trails.

1 investor

Cohesion builds AI agents that monitor earnings reports, podcasts, and social media posts to surface investment signals for hedge fund analysts, reducing the manual research work required to identify trading opportunities.

1 investor

Complir provides software to manage product compliance workflows for product teams, replacing legacy systems and manual processes. The platform helps companies reduce regulatory risk and accelerate time-to-market for physical products.

2 investors

Dayjob is an AI scheduling agent that integrates with job booking systems to automatically plan routes for service fleets, optimizing driver assignments based on travel times, skip sizes, and priorities. It serves waste management and logistics companies to reduce scheduling errors and improve operational efficiency.

2 investors

Deep Interactions is a collaborative AI builder that helps product teams scope, design, build, and deploy AI products while maintaining alignment across business goals, design, and technical execution. It integrates into existing tools and workflows to move teams from concept to production without prototype handoffs.

1 investor

Discovered Materials develops AI agents that accelerate materials discovery for semiconductor manufacturing, targeting datacenters and fabrication facilities. The company aims to find novel materials in months rather than years through AI-driven research combined with deep materials science expertise.

1 investor