Y Combinator Summer 2026 (S26) Companies

Omanta provides personalized scientific research support for complex disease cases, assigning PhD-level teams to build detailed molecular profiles from a patient's genomic, RNA, and protein data. It cross-references each patient's molecular profile against an internal reference cohort and biomedical literature to model therapeutic options and produce a research roadmap that informs the clinical team's decisions.</parameter> <parameter name="founders">[]

1 investor

OneCLI is an open-source credential gateway that secures AI agents by injecting API keys at the network layer, preventing agents and LLMs from accessing credentials directly. It works across any agent framework and enforces policies at the proxy level for endpoint blocking, rate limiting, and approval workflows.

2 investors

TrustAI provides workflow automation software that captures and distributes organizational knowledge and instincts through AI-driven suggestions, with transparency and human oversight. The platform enables teams to automate repetitive tasks while preserving judgment and expertise across the organization.

1 investor

Ooak Data is an applied AI research lab that converts real enterprise data into reinforcement learning environments for training AI agents. The company serves frontier AI labs, enterprise AI teams, and AI startups with multimodal data infrastructure and digital twins based on anonymized real-world company workflows.

4 investors

OpenRelay operates a distributed overlay network that connects consumer GPUs into a fault-tolerant mesh for inference workloads, automatically routing traffic around failed nodes without manual intervention. The platform allows anyone to contribute compute resources and deploy inference jobs via a single API call.

2 investors

Gini is a cloud-based AI agent that works inside team chat tools like Slack and Microsoft Teams, running sandboxed automations scoped to connected tools and permissions. It also maintains a self-updating company wiki sourced from chat threads, offering to take over recurring tasks for teams.

2 investors

OpenVector monitors video feeds to detect security events such as tailgating through building entrances and triggers automated responses like placing phone calls with attached clips. The product uses natural-language rules to configure physical security automations.

2 investors

Operon Solutions uses computer vision and AI to detect equipment, instruments, and piping in industrial process drawings with 97%+ accuracy, converting them into structured graph data. The platform enables engineers to query these drawings in natural language and generates standards-compliant P&IDs for industrial manufacturing and maintenance operations.

1 investor

Understudy Labs offers an open-source toolkit that captures traces from LLM production workflows, benchmarks and A/B tests cheaper or open-weight models against them, and fine-tunes and deploys specialist models that users own and can host anywhere. It is aimed at developers and teams looking to migrate from proprietary LLMs to models they control.

2 investors

Orvixo provides an AI-based production planning and scheduling system for manufacturers, modeling a factory's constraints, operating rules and planner knowledge to build and continuously adapt schedules. It connects to ERP/MRP data to plan across demand, materials, capacity and production, and replans when conditions such as rush orders, breakdowns or material delays change.

1 investor

OS3 develops hardware robots and AI models for autonomous deployment in real-world environments. The company designs its own robot hardware and trains models using human demonstration videos and reinforcement learning.

1 investor

Osmaura helps corporate law firms identify and pursue new matter opportunities with clients. The platform targets law firm partners seeking business development solutions in the legal services sector.

2 investors

Osseus builds a permissioned research brain that connects tools and data across R&D teams to surface past experiments, expert knowledge, and next actions. The platform serves technical and research teams in biotech, manufacturing, and similar knowledge-intensive industries by maintaining continuous memory of how work evolved and preventing repeated efforts.

2 investors

Pacific builds modular, containerized supercomputers ("pods") that deploy onto stalled construction sites with existing grid connections to provide AI compute infrastructure. It offers below-market hosted compute (GPU hours, tokens, training capacity) as well as managed on-premise pods for defense and regulated (CUI, CMMC) customers, including aerospace companies.

3 investors

Palette is a multimodal AI studio that turns a single prompt, image, or document into video, visuals, and structured content within one workflow, with editing, storyboarding, and character-consistency tools. It targets creators and businesses and offers an API for generating images, video, and music, along with enterprise features like ad generation and onboarding/training content.

2 investors

Palisade provides AI agents for online marketplaces, giving each buyer a personal agent that knows the catalog and pricing, giving sellers/owners an agent that explains their performance data, and routing high-intent leads to the operator's team. It installs via a single script tag and integrates with a company's booking engine, PMS, CRM, and catalog.

2 investors

Pango is an AI-powered operating system for e-commerce logistics that unifies shipping, tracking, returns, and post-purchase operations in a single platform. It automates operational workflows so e-commerce teams can make logistics decisions faster and scale across markets without proportional increases in complexity.

4 investors

Parasma develops algorithms and infrastructure to train living neural systems for computation, aiming to make advanced AI far more energy-efficient and accessible by leveraging biological neurons as programmable compute. The company serves organizations seeking to reduce the energy footprint and hardware costs of AI systems.

3 investors

Peer Freight is a technology-based freight brokerage that uses AI to generate rate quotes quickly, vet carriers, and monitor shipments, while keeping human support available. It specializes in hazmat freight and also handles reefer, dry van, flatbed, and port drayage loads, including oversize and hard-to-cover lanes.

2 investors

Pennant offers a proxy voting and corporate governance platform that lets institutional investors, corporate advisors, and public companies analyze meetings, filings, and proposals, apply custom voting policies, and record decisions with defensible rationale. The platform serves asset managers, owners, advisors, and corporate IR/governance teams managing proxy voting and shareholder engagement.

2 investors

Notyfi is a monitoring and notification service that tracks user-specified topics across news, filings, databases, and websites, delivering alerts via email, dashboard, or direct API integration into workflows and AI agents.

1 investor

Petrarch operates a marketplace that connects buyers and sellers of specialized datasets and proprietary information.

3 investors

Pluto is an AI voice agent that captures professional information through a 10-minute conversation and makes users discoverable to recruiters and AI agents. It helps professionals build a career profile they control and provides warm introductions to relevant job opportunities.

3 investors

PokerClubHub is a licensed online poker platform that lets individuals open and run their own poker clubs, handling all player deposits, withdrawals, and payments on the club owner's behalf and paying owners affiliate fees on rake. It serves poker club operators and players seeking a regulated alternative to unlicensed private clubs, with deposits secured through Fireblocks.

1 investor