Y Combinator Summer 2026 (S26) Companies

Luca IQ is a tax preparation platform for accounting firms and CPAs that handles the workflow from client intake and document collection through preparation, review, e-signature, delivery, and IRS e-filing. It structures source documents and provides an audit trail so every field traces back to its source, offered via a single API.

1 investor

Lumeria makes the Lumoscope, a multi-spectrum skin imaging scanner that clips onto a phone and uses RGB, UV, and polarized light to track skin conditions such as fine lines, tone, texture, pigment, and vascularity. Paired with an AI assistant called Lumi, it offers consumers personalized skincare routines, ingredient analysis, and progress tracking for at-home skin monitoring (not medical diagnosis).

1 investor

Machine0 provides on-demand persistent virtual machines with NixOS or Ubuntu, pre-installed development tools, and per-minute billing for developers and AI agents needing isolated compute resources. The service offers dedicated CPU/RAM, static IPs, and optional GPUs across multiple geographic regions.

1 investor

Maingen builds datasets and benchmarks from enterprise data to improve frontier AI models on industrial tasks, such as running industrial operations. Its SolarBench project measures whether models can operate an industrial operations desk.

1 investor

Manifold builds autonomous warehouse robots that perform case picking, palletizing, and trailer loading/unloading, combined with orchestration software that connects to existing ERP, WMS, and WES systems. It offers robotic labor to warehouse operators on a per-pick pricing model without upfront costs or major infrastructure retrofits.

1 investor

Truffle provides a unified operating system for restaurant back-of-house operations, using computer vision, voice AI, and machine learning to automate inventory tracking, demand forecasting, and workflows like procurement, scheduling, and food preparation.

1 investor

Markov Studios captures screen recordings and interaction data from real computer use to create datasets that machine learning models can learn from. The company produces labeled data from real workflows in productivity software and video games.

1 investor

Mireye provides an API that converts geographic coordinates into structured, sourced data about physical terrain, buildings, infrastructure, and environmental risk for AI agents. The platform aggregates U.S. federal datasets (USGS, NOAA, FEMA, and others) and returns data with full provenance and confidence ratings.

1 investor

Molagri develops biopesticides that target harmful insects through specific molecular mechanisms while protecting beneficial insects and the environment, and incorporates resistance modeling to maintain product efficacy over time.

1 investor

Nebula Security uses AI-driven security pipelines to accelerate vulnerability research in widely used software such as operating systems, browsers, and applications. The company identifies security bugs and vulnerabilities significantly faster than traditional manual research methods.

1 investor

Neuron Industries builds Cortex, an AI-native industrial controller that replaces the traditional PLC, HMI, historian, and vendor IDE in a single device, letting controls engineers describe machine behavior in plain English and generate auditable real-time Python code. The platform serves industrial automation and controls-engineering teams working on machines, skids, retrofits, and production lines, with a built-in browser IDE, wiring discovery, robot control, on-device historian, and simulation-based testing.

1 investor

Nex builds AI agents that connect to 1000+ integrations to automate manual workflows across business tools like HubSpot, Gmail, and Slack. The platform detects team patterns and deploys autonomous agents that improve over time, unifying fragmented software stacks into a shared knowledge graph for enterprise teams.

2 investors

Nori Robotics manufactures household robots that autonomously handle domestic tasks like cleaning, organizing, and food preparation. The robots can learn and share skills via a marketplace, and support remote operation for household assistance.

1 investor

Olam Labs builds multiplayer game environments — such as no-limit Texas hold'em, Risk-style conquest, Codenames-style word deduction, and market simulations — to study how AI agents negotiate, socialize, and compete alongside humans. It also runs large-scale internal simulations with hundreds of concurrent agents and publishes notable research runs.

1 investor

Omanta provides personalized scientific research support for complex disease cases, assigning PhD-level teams to build detailed molecular profiles from a patient's genomic, RNA, and protein data. It cross-references each patient's molecular profile against an internal reference cohort and biomedical literature to model therapeutic options and produce a research roadmap that informs the clinical team's decisions.</parameter> <parameter name="founders">[]

1 investor

OneCLI is an open-source credential gateway that secures AI agents by injecting API keys at the network layer, preventing agents and LLMs from accessing credentials directly. It works across any agent framework and enforces policies at the proxy level for endpoint blocking, rate limiting, and approval workflows.

1 investor

Ooak Data is an applied AI research lab that converts real enterprise data into reinforcement learning environments for training AI agents. The company serves frontier AI labs, enterprise AI teams, and AI startups with multimodal data infrastructure and digital twins based on anonymized real-world company workflows.

1 investor

OpenRelay operates a distributed overlay network that connects consumer GPUs into a fault-tolerant mesh for inference workloads, automatically routing traffic around failed nodes without manual intervention. The platform allows anyone to contribute compute resources and deploy inference jobs via a single API call.

1 investor

OpenTrade makes stock market games that use real companies and market stories, allowing players to make investment calls and compare results with friends. The platform is designed for everyday investors who want to learn about market mechanics through gameplay.

1 investor

OpenVector monitors video feeds to detect security events such as tailgating through building entrances and triggers automated responses like placing phone calls with attached clips. The product uses natural-language rules to configure physical security automations.

1 investor

Operon Solutions uses computer vision and AI to detect equipment, instruments, and piping in industrial process drawings with 97%+ accuracy, converting them into structured graph data. The platform enables engineers to query these drawings in natural language and generates standards-compliant P&IDs for industrial manufacturing and maintenance operations.

1 investor

Orvixo provides an AI-based production planning and scheduling system for manufacturers, modeling a factory's constraints, operating rules and planner knowledge to build and continuously adapt schedules. It connects to ERP/MRP data to plan across demand, materials, capacity and production, and replans when conditions such as rush orders, breakdowns or material delays change.

1 investor

OS3 develops hardware robots and AI models for autonomous deployment in real-world environments. The company designs its own robot hardware and trains models using human demonstration videos and reinforcement learning.

1 investor

Osmaura helps corporate law firms identify and pursue new matter opportunities with clients. The platform targets law firm partners seeking business development solutions in the legal services sector.

1 investor