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Trefoil Therapeutics

San Diego, US · Founded 2016 · Delaware corporation · 8 known investors

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Trefoil Therapeutics is a clinical-stage biotechnology company developing therapeutic agents for corneal diseases. Its lead investigational candidate, TTHX1114, is being studied in a Phase 2 trial for improving visual recovery after Descemet Stripping Only (DSO) procedures.

Founders & leadership

Trefoil Therapeutics was founded in 2016 by David Eveleth.

DEDavid Eveleth
David EvelethPresident, CEO and Founder2013–2025David Eveleth founded Trefoil Therapeutics, a clinical-stage biotech company developing regenerative therapies for corneal diseases, and has over 30 years of experience in ophthalmology, neuroscience, and regenerative medicine across scientific and commercial roles.
SNSchalon Newton
Schalon NewtonChief Business Officer2015–2024Schalon Newton held the role of Chief Business Officer at Trefoil Therapeutics, where he directed corporate strategy and financing for ophthalmic therapies, and previously served as President of Allergan's Japan subsidiary. He has over four decades of experience in biotechnology, specialty pharmaceuticals, and medical devices, with expertise in capital formation, M&A, and international market expansion.

Board

CSChristy Shaffer
Christy ShafferChair of the Board of Directors
RB
Ralph BradshawBoard director

Investors · 8

Funding

SEC filings, press & company announcements

$33.3M disclosed across 4 of 5 rounds · 2016–2025

▶$4.6MraisedMay 2025 · 16 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Christy ShafferDirector
  • Stella RobertsonDirector
  • Jonathan MowExecutive Officer
  • Ben McGrawDirector
  • John FucciDirector
  • Kseniya SimpsonDirector
Offering amount
$5M
Amount sold
$4.6M
First sale
Apr 2025
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$12MraisedMar 2022 · 14 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Christy ShafferDirector
  • Derek YoonDirector
  • Stella RobertsonDirector
  • Ben McGrawDirector
  • David EvelethExecutive Officer, Director
  • Schalon NewtonExecutive Officer
Offering amount
$12M
Amount sold
$12M
First sale
Mar 2022
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$12.6MraisedAug 2019 · 13 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Christy ShafferDirector
  • Derek YoonDirector
  • Stella RobertsonDirector
  • Schalon NewtonExecutive Officer
  • David EvelethExecutive Officer, Director
  • Ben McGrawDirector
Offering amount
$28M
Amount sold
$12.6M
First sale
Jul 2019
Incorporated
Corporation, Delaware, 2016
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$4.2MraisedDec 2016 · 14 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Ralph BradshawDirector
  • Christy ShafferDirector
  • Schalon NewtonExecutive Officer
  • David EvelethExecutive Officer, Director
Offering amount
$5.2M
Amount sold
$4.2M
First sale
Dec 2016
Incorporated
Corporation, Delaware, 2016
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

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In the news

Frequently asked questions

What does Trefoil Therapeutics do?
Trefoil Therapeutics is a clinical-stage biotechnology company developing therapeutic agents for corneal diseases. Its lead investigational candidate, TTHX1114, is being studied in a Phase 2 trial for improving visual recovery after Descemet Stripping Only (DSO) procedures.
Who founded Trefoil Therapeutics?
Trefoil Therapeutics was founded by David Eveleth in 2016.
Who are Trefoil Therapeutics's investors?
Trefoil Therapeutics's investors include ExSight Ventures, Hatteras Venture Partners, Solasta Ventures, Access Biotechnology, Bios Partners, Correlation Ventures, FemHealth Ventures, InFocus Capital Partners, LLC.
How much funding has Trefoil Therapeutics raised?
Trefoil Therapeutics has disclosed $33.3M raised across 4 of its 5 known rounds.
Where is Trefoil Therapeutics headquartered?
Trefoil Therapeutics is headquartered in San Diego, US.