Trefoil Therapeutics
San Diego, US · Founded 2016 · Delaware corporation · 8 known investors
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Trefoil Therapeutics is a clinical-stage biotechnology company developing therapeutic agents for corneal diseases. Its lead investigational candidate, TTHX1114, is being studied in a Phase 2 trial for improving visual recovery after Descemet Stripping Only (DSO) procedures.
Founders & leadership
Trefoil Therapeutics was founded in 2016 by David Eveleth.


Board

Investors · 8
How we know: ExSight Ventures's portfolio page · the company's own site · open dataset · 5k.vc investor directory · Not right? Tell us
How we know: the company's own site · a partner's Signal profile · funding news · the VCSheet dataset · Not right? Tell us
How we know: the company's own site · open dataset · 5k.vc investor directory · Not right? Tell us
How we know: the company's own site · funding news · Not right? Tell us
How we know: the company's own site · board seat on SEC Form D · funding news · Not right? Tell us
How we know: the company's own site · Not right? Tell us
Funding
SEC filings, press & company announcements$33.3M disclosed across 4 of 5 rounds · 2016–2025
- Undisclosed amountSeries ADec 2021Source ↗
▶$4.6MraisedMay 2025 · 16 investors · BiotechnologyRule 506(b)
- Christy ShafferDirector
- Stella RobertsonDirector
- Jonathan MowExecutive Officer
- Ben McGrawDirector
- John FucciDirector
- Kseniya SimpsonDirector
- Offering amount
- $5M
- Amount sold
- $4.6M
- First sale
- Apr 2025
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$12MraisedMar 2022 · 14 investors · BiotechnologyRule 506(b)
- Christy ShafferDirector
- Derek YoonDirector
- Stella RobertsonDirector
- Ben McGrawDirector
- David EvelethExecutive Officer, Director
- Schalon NewtonExecutive Officer
- Offering amount
- $12M
- Amount sold
- $12M
- First sale
- Mar 2022
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$12.6MraisedAug 2019 · 13 investors · BiotechnologyRule 506(b)
- Christy ShafferDirector
- Derek YoonDirector
- Stella RobertsonDirector
- Schalon NewtonExecutive Officer
- David EvelethExecutive Officer, Director
- Ben McGrawDirector
- Offering amount
- $28M
- Amount sold
- $12.6M
- First sale
- Jul 2019
- Incorporated
- Corporation, Delaware, 2016
- Federal exemptions
- 06b
▶$4.2MraisedDec 2016 · 14 investors · BiotechnologyRule 506(b)
- Ralph BradshawDirector
- Christy ShafferDirector
- Schalon NewtonExecutive Officer
- David EvelethExecutive Officer, Director
- Offering amount
- $5.2M
- Amount sold
- $4.2M
- First sale
- Dec 2016
- Incorporated
- Corporation, Delaware, 2016
- Federal exemptions
- 06b
Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.
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In the news
Frequently asked questions
- What does Trefoil Therapeutics do?
- Trefoil Therapeutics is a clinical-stage biotechnology company developing therapeutic agents for corneal diseases. Its lead investigational candidate, TTHX1114, is being studied in a Phase 2 trial for improving visual recovery after Descemet Stripping Only (DSO) procedures.
- Who founded Trefoil Therapeutics?
- Trefoil Therapeutics was founded by David Eveleth in 2016.
- Who are Trefoil Therapeutics's investors?
- Trefoil Therapeutics's investors include ExSight Ventures, Hatteras Venture Partners, Solasta Ventures, Access Biotechnology, Bios Partners, Correlation Ventures, FemHealth Ventures, InFocus Capital Partners, LLC.
- How much funding has Trefoil Therapeutics raised?
- Trefoil Therapeutics has disclosed $33.3M raised across 4 of its 5 known rounds.
- Where is Trefoil Therapeutics headquartered?
- Trefoil Therapeutics is headquartered in San Diego, US.





