System Inc

System Inc. is a New York City-based software company, organized as a Public Benefit Corporation, that builds tools to represent interconnected data and knowledge as a single system rather than as disciplinary or scale-based silos. Its central asset is the System Graph, described as a platform combining large language models, graph technology, complexity science, and causal-inference techniques to construct a unified model of the world from millions of quantitative relationships drawn across sources and fields.

The company's commercial product, positioned as "search reinvented for research," is used to find, synthesize, and contextualize scientific literature, starting with health and life sciences. It uses AI to extract, relate, and visualize research findings, synthesizes evidence for a given paper, topic, variable, or relationship between variables, exposes the underlying source studies and statistical methods behind each relationship, places findings in the context of adjacent areas, and lets users filter results by population characteristics. A separate offering referenced on the site is WholeHealth, and the site's sales intake lists use cases including access to structured clinical knowledge and ontologies, diagnostic accuracy and clinical decision support, alignment with current clinical guidelines, population health risk management, and embedding clinical intelligence into third-party products. Third-party directory coverage characterizes the software more broadly as helping businesses, non-profits, and research organizations map interconnected components, visualize relationships, and support decision-making and strategic planning.

Founding story

Adam Bly founded System and serves as its Founder and CEO.

Business model

System sells access to its software to organizations, with a self-service free sign-up tier alongside enterprise engagement through demo requests and a sales contact process. Alongside commercial licensing, the company has committed to providing free and open access to the System Graph for non-commercial use and to publishing open-source tools and downloadable data, funded in part by a philanthropic program-related investment.

Software product with a free sign-up tier and a paid/enterprise track (System Pro is referenced in product FAQs), supplemented by a program-related investment from a philanthropic funder supporting open, non-commercial access.

Traction

Testimonials from practising physicians and academic researchers, including clinicians in family medicine and infectious diseases and an epidemiologist at the UVA School of Medicine; named organizational customers The Novartis Foundation and Atropos Health; and disclosed venture and philanthropic funding totalling over $15 million in venture capital plus a $6.5 million Wellcome investment.

Latest developments

In December 2025 System announced a $6.5 million program-related investment from Wellcome to fund free and open non-commercial access to the System Graph, open-source tools for generating living evidence-based systems maps with an initial focus on public health and biomedical research, and an annual conference on systems-based solutions; the company said it would begin releasing System Graph snapshots into the commons in 2026. Danny Hillis joined as an advisor. As of the latest site snapshot the careers page lists no open positions.