Simplex was founded by Shreya Karpoor, Marco Nocito in 2024.

Who are Simplex's investors?

Simplex's investors include FundersClub, Pioneer, Sterling Road, The E14 Fund, Y Combinator, Bitmain, Capitalize VC, Korea Investment Partners and 2 more.

Where is Simplex headquartered?

Simplex is headquartered in San Francisco, US.

Simplex

YC S24

San Francisco, US · Founded 2024 · 2 employees · 10 known investors

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Simplex provides automated provider enrollment management for healthcare networks, handling CAQH profile setup, payer applications, and compliance tracking across multiple states and insurers. The platform uses AI agents to submit applications, monitor status, fix corrections, and deliver final enrollment determinations with full audit trails.

Also known as Simplex Labs, Inc. · Pansimulate · Simplex, Pansimulate

AI & Machine Learning Developer Tools Enterprise Software Healthtech Machine Learning Robotic Process Automation B2B AIUnited States of AmericaAmerica / Canada

Founders & leadership· Y Combinator alumni (S24)

Simplex was founded in 2024 by Shreya Karpoor and Marco Nocito.

Shreya Karpoor Co-founder and CEOShe holds degrees in electrical engineering and computer science from MIT and has prior experience in software development at Tesla and robotics research at MIT.

Marco Nocito Co-founder and CTOMarco Nocito holds degrees in Computer Science from MIT and has prior experience building machine learning models at Waymo, developing data infrastructure at Viam, and working at Bloomberg. He is co-founder and CTO of Simplex.

Investors · 10

FundersClublisted by FundersClubSan Francisco · $290K

How we know: funding news · Not right? Tell us

Pioneerlisted by PioneerToronto, Ontario

How we know: Y Combinator's founder network · pioneerfund.vc · open dataset · 5k.vc investor directory · Not right? Tell us

Sterling Roadlisted by Sterling RoadSan Francisco · $25K – $150K

How we know: Sterling Road's portfolio page · the VCSheet dataset · Y Combinator's founder network · Not right? Tell us

The E14 Fundlisted by The E14 FundCambridge · $1M – $5M

How we know: Y Combinator's founder network · e14.vc · Not right? Tell us

Y Combinatorlisted by Y CombinatorSan Francisco · $500K

How we know: the Y Combinator directory · funding news · open dataset · 5k.vc investor directory · Not right? Tell us

Bitmainreported

How we know: funding news · Not right? Tell us

Capitalize VCreportedChicago · $100K – $200K

How we know: Y Combinator's founder network · Not right? Tell us

Korea Investment PartnersreportedSeoul · $3M – $10M

How we know: open dataset · 5k.vc investor directory · Not right? Tell us

Orange CollectivereportedDanville

How we know: Y Combinator's founder network · Not right? Tell us

SBXireportedCambridge · $10K – $1M

How we know: Y Combinator's founder network · Not right? Tell us

Funding

SEC filings, press & company announcements

Undisclosed amountSeries ADec 2022
Source ↗

Source: company announcements and press reports — follow each round's link for the claim.

Images

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OntoraOntora provides an AI agent that conducts parallel interviews with employees across an organization to map business processes and identify bottlenecks in operations, sales, and finance. The platform accelerates process discovery and operational transformation by extracting undocumented workflows from employee knowledge.

Companies working in the same space as Simplex.

Legal entities · 1

corporate structure

Simplex Labs, Inc.

In the news

Simplex - enterprise-grade web agentsycombinator.com · May 2025

Simplex - Web automation for developersycombinator.com · Jan 2025

13 companies from YC Demo Day 1 that are worth paying attention totechcrunch.com · Sep 2024

Simplex: on-demand photorealistic vision datasetsycombinator.com · Aug 2024

Frequently asked questions

What does Simplex do?: Simplex provides automated provider enrollment management for healthcare networks, handling CAQH profile setup, payer applications, and compliance tracking across multiple states and insurers. The platform uses AI agents to submit applications, monitor status, fix corrections, and deliver final enrollment determinations with full audit trails.
Who founded Simplex?: Simplex was founded by Shreya Karpoor, Marco Nocito in 2024.
Who are Simplex's investors?: Simplex's investors include FundersClub, Pioneer, Sterling Road, The E14 Fund, Y Combinator, Bitmain, Capitalize VC, Korea Investment Partners and 2 more.
Where is Simplex headquartered?: Simplex is headquartered in San Francisco, US.