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Orange Grove Bio

Cincinnati, US · Founded 2019 · Delaware LLC · 29 employees on LinkedIn · 2 known investors

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Orange Grove Bio is a biotech venture firm that builds and backs cell therapy and immuno-oncology companies, forming subsidiary companies (subcos) such as Ipinovyx and DomainOne Therapeutics. It operates in the biopharmaceutical and life sciences investment space.

BiotechDeep TechHealthtechLongevity

Founders & leadership

MKMichael Kalos
Michael KalosSenior Venture Partner & Head of Cell TherapyMichael Kalos holds a PhD from the University of Minnesota and completed postdoctoral training at the Fred Hutchinson Cancer Research Center. He spent a decade in academia at the University of Pennsylvania and City of Hope National Medical Center directing translational research laboratories, followed by senior roles at Eli Lilly (Chief Scientific Officer, Immunooncology), Janssen (Vice President, Immuno-Oncology and Oncology Cell Therapies), and ArsenalBio (EVP, Head of R&D), and currently serves as Senior Venture Partner at Orange Grove Bio and Founder and Managing Director of Next Pillar Consulting.
MA
Marc AppelNamed on SEC filing

Investors · 2

Alley Robotics VenturesreportedCohasset · $500K – $2Mvia Abe Murray · inferred

How we know: the VCSheet dataset · Not right? Tell us

Reported raises · per SEC filings

Form D private placements

$16.6M disclosed across 1 round · 2022

▶$16.6MraisedAug 2022 · 15 investors · Other Health Care
Rule 506(b)
Officers, directors & promoters on the filing
  • Marc AppelExecutive Officer, Director
Offering amount
$30M
Amount sold
$16.6M
First sale
Aug 2022
Incorporated
Limited Liability Company, Delaware, 2019
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

Founder mafia

2 people who came through Orange Grove Bio went on to found or lead other companies.

Michael KalosSenior Venture Partner & Head of Cell TherapyFounded IpiNovyx BioRachel GarlickSenior AssociateFounded Eris Biotech

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Companies working in the same space as Orange Grove Bio.

In the news

Orange Grove Bio Closes on New Financing Round to Advance Strategic Initiatives and Welcomes Salvatore Cremona as New Chief Executive Officerorangegrovebio.com · Aug 2025Orange Grove Bio and University of Chicago Form Strategic Partnership to Accelerate Biotech Innovation and Commercializationorangegrovebio.com · Jul 2024Orange Grove Bio: Filling the Gap in Preclinical Drug Developmentorangegrovebio.com · Jan 2020

Frequently asked questions

What does Orange Grove Bio do?
Orange Grove Bio is a biotech venture firm that builds and backs cell therapy and immuno-oncology companies, forming subsidiary companies (subcos) such as Ipinovyx and DomainOne Therapeutics. It operates in the biopharmaceutical and life sciences investment space.
Who are Orange Grove Bio's investors?
Orange Grove Bio's investors include AlleyCorp, Alley Robotics Ventures.
How much funding has Orange Grove Bio raised?
Orange Grove Bio has disclosed $16.6M raised across 1 round.
Where is Orange Grove Bio headquartered?
Orange Grove Bio is headquartered in Cincinnati, US.