/Companies

Amissa

Techstars '26

Charlotte, US · 14 employees on LinkedIn · 2 known investors

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Amissa Health quantifies symptoms through wearable data and biometric collection to improve clinical care and research, with a focus on early detection of Alzheimer's and digital biomarkers for perimenopause in women. The company serves healthcare institutions, researchers, and patients seeking personalized treatment guidance.

Also known as Amissa Health

Founders & leadership

SSSam Smith
Sam SmithFounder & CEOSam Smith is founder and CEO of Amissa Health, a company building clinical data infrastructure for menopause care using wearable data and health platform integrations. She previously founded Seed the South, a startup and investor event in Charlotte, and has led venture-backed startups focused on applying technology and AI to operational efficiency.
JCJon Corkey
Jon CorkeyFounder & CSOJon Corkey founded Amissa, a digital health company focusing on wearable data and biometric collection to detect early-stage diseases and identify clinical biomarkers. He previously served 25 years as a Navy Special Operations Officer, including roles in military security and technology research for operational advancement.

Board

DJDr. Jaclyn Piasta
Dr. Jaclyn PiastaFounder, Monarch Health

Investors · 2

Techstarslisted by TechstarsBoulder · $220K

How we know: the Techstars portfolio · open dataset · Top 3000 Accelerator Startups (no YC) 2026-08 · Not right? Tell us

Company profile

researched Sep 2026

Amissa is a Charlotte, North Carolina health technology company that builds a platform to connect patient-generated symptom data with clinical workflows, with a current focus on menopause and perimenopause care. The platform aggregates three categories of data: the Menopause Rating Scale questionnaire, completed during patient onboarding and pre-appointment intake; ongoing patient self-tracking of symptoms; and passive data from consumer wearables including the Apple Watch, Oura, Garmin and Whoop, which contribute signals on sleep and fatigue.

These inputs are consolidated into a single reviewable clinical record within the provider's electronic health record, and AI is used to produce a short digest that a clinician can read in roughly 30 seconds immediately before an appointment. The intent is to give clinicians visibility into how symptoms change before, during and between visits so that treatment can be adjusted, and to reduce the burden on patients to recall details during short appointments. Earlier company materials describe Amissa Health as an AI platform built on cloud-scale data analytics for remote patient monitoring with wearable devices, applied to rare disease and dementia prevention including Alzheimer's and Parkinson's.

Founding story

Co-founder and CEO Sam Smith entered the startup sector after roughly 15 years of industry experience and a background in journalism, and cites her mother's two decades of untreated menopause symptoms as motivation for addressing a neglected area of women's health. Co-founder Jon Corkey is a retired Navy Special Operations Officer whose military career was cut short by a rare disease diagnosis, which led him to help build a wearable-based monitoring platform aimed at dementia and rare disease.

Business model

Amissa sells a B2B software platform to clinical practices, charging a per-clinician fee for access. It does not sell wearables, supplements or medications and does not provide medical advice directly to patients, which the company describes as limiting its regulatory exposure while still monetizing patient-generated health data.

Providers pay a recurring per-clinician fee for access to the platform.

Traction

By January 2026 Amissa was working with 10 clinical practices across the United States, including Helia Health. The company reports monthly active usage rates above industry norms and an average of 120 symptoms tracked per patient per month, and cites a case in which a Charlotte clinician used Amissa's tracking history to adjust medication for a patient with menopause-related depression.

Latest developments

As of July 2026 the company reported three employees, was piloting with Charlotte clinicians, had secured a commitment from Primordial Ventures and an angel investor, and was working to close its pre-seed round.

▸Full profile — market position, technology, go-to-market, geography, history, risks & controversies

Market position

Amissa operates in a menopause and perimenopause care market that is drawing increasing attention and new entrants; adjacent companies named alongside it include the virtual menopause providers Midi Health, Evernow and Gennev. Amissa differs from these in selling clinician-facing data infrastructure rather than direct care, and describes its position relative to wearable makers such as Oura and Whoop as complementary rather than competing.

Company leadership positions Amissa as the only platform focused on the connectivity layer between patient data and clinicians in menopause care, as opposed to virtual care providers, wearables, supplements or medication. Rather than expecting clinicians to interpret wearable PDFs during a 15-minute appointment, the product standardizes fragmented inputs into a short pre-visit summary, and adds symptom fields that the company says are absent from standard EHRs.

Technology

The platform integrates with consumer wearables (Apple Watch, Oura, Garmin, Whoop), structured questionnaires such as the Menopause Rating Scale, patient-entered symptom logs and EHR data, and applies AI to consolidate them into a concise clinical summary delivered inside the provider's EHR. Earlier descriptions characterize the system as cloud-scale data analytics for remote patient monitoring via smartwatches.

Go-to-market

Amissa validated its concept through customer discovery interviews with more than 500 clinicians, researchers, health system leaders and patients, and is piloting the application with local clinicians in Charlotte to refine the user experience before broader expansion. Participation in the Techstars AI Health program in Baltimore provided access to organizations including MedStar, Johns Hopkins and Blue Cross Blue Shield.

Clinical practices and the clinicians within them — particularly OB-GYNs and primary care physicians treating women in perimenopause and menopause — and, indirectly, the patients who track symptoms on the platform. The company notes research finding that 93% of OB-GYN and primary care residents do not feel comfortable managing menopausal symptoms.

Geography

Headquartered in Charlotte, North Carolina, with pilot deployments among local Charlotte clinicians and clinical practices across the United States; the company participated in an accelerator program based in Baltimore.

History

The company was founded in 2017 and initially operated as Amissa Health, a bootstrapped AI platform using smartwatches to remotely monitor patient mental and physical health in the context of rare diseases and dementia, including Alzheimer's and Parkinson's; it was led at that time by Jon Corkey, a retired Navy Special Operations Officer whose military career ended with a rare disease diagnosis. In October 2023 the company won the Charlotte Veteran Startup Showcase and a $50,000 grant. Early development was supported by a National Institutes of Health Small Business Innovation Research grant, which funded an extended customer discovery phase. The company publicly launched its AI menopause care platform in January 2026, participated in the Techstars AI Health program in Baltimore, and as of July 2026 was working to close a pre-seed round.

Risks & controversies

The company was still finalizing its pre-seed round as of July 2026 with a team of three, and its clinical footprint remains small at approximately 10 practices. Management notes that the menopause and perimenopause category is attracting a growing number of competitors.

Compiled by commissioned research from 4 cited public sources — announcements, filings, and press listed under research sources below.

Key figures

latest reported
Clinical practices using the platformJan 202610 practices
Clinicians, researchers, health system leaders and patients interviewed during cJul 2026500 interviews
HeadcountAug 202614
Symptoms tracked per patient per month (average)Jul 2026120 symptoms
Team sizeJul 20263 employees

Company-reported or press-reported figures, each dated to when it was claimed — not independently audited.

Related companies · 6

AlloyAlloy is a telehealth service that connects women in midlife and menopause with board-certified, menopause-trained doctors for treatments including hormone therapy, GLP-1 weight care, skincare, sexual health, hair and gut health. It offers online intake, ongoing messaging with physicians, and cash-pay/FSA-HSA-eligible prescription products.
Flo HealthFlo is a women's health app offering personalized cycle tracking, fertility guidance, pregnancy support, and health education backed by a medical team. The app serves women and people with periods globally with science-based insights on hormonal health from first period to perimenopause.
EvernowEvernow provides virtual menopause care for women, offering one-time video visits and ongoing membership access to certified menopause providers who prescribe hormone therapy and estrogen replacement. It also sells medically curated supplements targeting menopause symptoms such as sleep, mood, energy, skin, and metabolism.
Midi HealthMIDI develops digital health solutions for patients and clinicians to improve access to and delivery of care across diverse populations. The company takes an experimental approach to building tools that address unmet clinical needs.
GennevGennev is a telehealth clinic focused on menopause care, offering video appointments with board-certified, menopause-trained doctors and evidence-based treatment for women from perimenopause through post-menopause. It provides symptom relief, medical questionnaires, and insurance-based payment options.
Natural CyclesNatural Cycles offers an FDA-cleared mobile app that uses a user's body temperature data and an algorithm to predict fertile windows for hormone-free birth control and pregnancy planning. The app supports women's health across life stages from contraception through perimenopause and is certified in over 35 countries.

Companies working in the same space as Amissa.

Non-dilutive funding · 1 SBIR/STTR award

Federal grants — no equity taken
AgencyPhaseYearAmount
National Institutes of Health (NIH)National Institutes of HealthPhase I2021$495.8K

Source: SBIR.gov award data (U.S. Small Business Administration). SBIR/STTR awards are competitive federal R&D grants and contracts — non-dilutive capital alongside any venture rounds above.

Timeline · 5

launches, deals, and filings
Jul 2026
Participation in Techstars AI Health program in Baltimore

Amissa took part in the Techstars AI Health accelerator in Baltimore, gaining access to networks including MedStar, Johns Hopkins and Blue Cross Blue Shield; the program concluded with a Demo Day.

source ↗

Jul 2026
Investment partnership with Primordial Ventures

Primordial Ventures committed to invest in Amissa following an introduction to CEO Sam Smith at a local charity event and months of relationship building.

source ↗

Jan 2026
NIH Small Business Innovation Research grant

Amissa is a recipient of a National Institutes of Health Small Business Innovation Research (SBIR) grant, which funded early development and the customer discovery phase.

source ↗

Jan 2026
Amissa launches AI platform for menopause care

Amissa publicly launched an AI-powered platform that aggregates Menopause Rating Scale questionnaire responses, patient self-tracked symptoms and wearable data into a single reviewable clinical record inside the provider's EHR.

source ↗

Oct 2023
Amissa Health wins Charlotte Veteran Startup Showcase and $50,000 grant

Amissa Health, led by retired Navy Special Operations Officer Jon Corkey, won the Annual Charlotte Veteran Startup Showcase pitch contest sponsored by the Service First Foundation, securing a $50,000 cash grant for its AI platform using smartwatches to remotely monitor patient mental and physical health.

$50K source ↗

Dated company events from announcements, filings, and press; legal rows summarize public dockets and regulator releases.

In the news

▸Research sources · 4

primary sources listed

4 public sources were cited for this profile; the first-party ones are listed here.

Frequently asked questions

What does Amissa do?
Charlotte-based health tech company whose AI platform channels patient symptom and wearable data into clinicians' EHR workflows for menopause care.
Who founded Amissa?
Amissa was founded by Sam Smith, Jon Corkey.
Who are Amissa's investors?
Amissa's investors include Primordial Ventures, Techstars.
Where is Amissa headquartered?
Amissa is headquartered in Charlotte, US.