/Companies

Aileron Therapeutics

NASDAQ: RNTX

Cambridge, US · Founded 2025 · Delaware corporation · 17 employees on LinkedIn · 2 known investors

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Aileron Therapeutics is a clinical-stage biopharmaceutical company developing peptide and protein-based therapies for rare lung and fibrosis diseases. The company is primarily advancing LTI-03, a peptide derived from the Cav1 protein for idiopathic pulmonary fibrosis, which has completed Phase 1b testing and is now in Phase 2 clinical development.

Founders & leadership

MAManuel Aivado
Manuel AivadoExecutiveManuel Aivado is an executive in biopharmaceuticals with experience in R&D, finance, and business development, and previously worked as a physician with board certification in internal medicine, hematology, and medical oncology in Germany. He conducted research at Harvard Medical School's Libermann Lab and has authored over 50 peer-reviewed publications and multiple patent applications.
BWBrian Windsor
Brian WindsorPresident and Chief Executive Officer; Director

Board

CW
Caleb WinderBoard directorManaging Director at Excel Venture Management
SL
Seth L. HarrisonBoard director
RJ
Reinhard J. AmbrosBoard director
JA
Joseph A. Yanchik IIICo-Founder, CEO & Director2005–2018Venture Partner at Apple Tree Venture Management Llc
BM
Brian M. Gallagher, Jr.Board director
AS
Armen ShanafeltBoard director
SK
Scott KapnickBoard director
EP
Enrico PetrilloBoard director
JH
John H. McArthurBoard director

Investors · 2

Reported raises · per SEC filings

Form D private placements

$68.2M disclosed across 3 rounds · 2014–2023

▶$18.3MraisedNov 2023 · 15 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Alan MussoDirector
  • Reinhard J. AmbrosDirector
  • Nolan Sigal, M.D., Ph.D.Director
  • William FaireyDirector
  • Josef H. von RickenbachDirector
  • Manuel Alves-Aivado, M.D., Ph.D.Executive Officer, Director
  • Brian Windsor, Ph.D.Executive Officer
  • Susan L. DrexlerExecutive Officer
Offering amount
$18.3M
Amount sold
$18.3M
Sales commissions
$752.8K
Placement agents
Arcadia Securities, LLC, Clear Street LLC
First sale
Nov 2023
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$30.1MraisedJan 2017 · 11 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Manuel AivadoExecutive Officer
  • Caleb WinderDirector
  • Seth L. HarrisonDirector
  • John H. McArthurDirector
  • Reinhard J. AmbrosDirector
  • Joseph A. Yanchik IIIExecutive Officer, Director
  • Brian M. Gallagher, Jr.Director
  • Armen ShanafeltDirector
  • Scott KapnickDirector
Offering amount
$40M
Amount sold
$30.1M
First sale
Dec 2016
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$19.8MraisedOct 2014 · 13 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Joseph A. Yanchik IIIExecutive Officer, Director
  • Seth L. HarrisonDirector
  • Brian M. Gallagher, Jr.Director
  • Armen ShanafeltDirector
  • Reinhard J. AmbrosDirector
  • Scott KapnickDirector
  • John H. McArthurDirector
  • Enrico PetrilloDirector
Offering amount
$33M
Amount sold
$19.8M
First sale
Oct 2014
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

Founder mafia

2 people who came through Aileron Therapeutics went on to found or lead other companies.

Frequently asked questions

What does Aileron Therapeutics do?
Aileron Therapeutics is a clinical-stage biopharmaceutical company developing peptide and protein-based therapies for rare lung and fibrosis diseases. The company is primarily advancing LTI-03, a peptide derived from the Cav1 protein for idiopathic pulmonary fibrosis, which has completed Phase 1b testing and is now in Phase 2 clinical development.
Who are Aileron Therapeutics's investors?
Aileron Therapeutics's investors include Excel Venture Management, Novartis Venture Fund.
How much funding has Aileron Therapeutics raised?
Aileron Therapeutics has disclosed $68.2M raised across 3 rounds.
Where is Aileron Therapeutics headquartered?
Aileron Therapeutics is headquartered in Cambridge, US.