Tvardi Therapeutics
NASDAQ: TVRDHouston, US · Founded 2017 · Delaware corporation · 20 employees on LinkedIn · 2 known investors
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Tvardi Therapeutics is a clinical-stage biopharmaceutical company developing oral small molecule STAT3 inhibitors to treat inflammatory and proliferative diseases. Its pipeline includes TTI-101, a direct STAT3 inhibitor in a Phase 2 trial for hepatocellular carcinoma, and TTI-109, a phosphate prodrug of TTI-101.
Founders & leadership
Tvardi Therapeutics was founded in 2017 by David J. Tweardy.

Board
Investors · 2
Reported raises · per SEC filings
Form D private placements$78.2M disclosed across 3 rounds · 2014–2021
▶$72.4MraisedJun 2021 · 32 investors · BiotechnologyRule 506(b)
- Jamie McNabDirector
- Michael WyzgaDirector
- Wallace HallDirector
- Imran AlibhaiExecutive Officer, Director
- Sujal ShahDirector
- Offering amount
- $75.1M
- Amount sold
- $72.4M
- First sale
- Jun 2021
- Incorporated
- Corporation, Delaware, 2017
- Federal exemptions
- 06b
▶$5.6MraisedJul 2018 · 8 investors · PharmaceuticalsRule 506(b)
- Ronald DePinhoDirector
- David J. TweardyExecutive Officer, Director
- Offering amount
- $8.5M
- Amount sold
- $5.6M
- First sale
- Jun 2018
- Incorporated
- Corporation, Delaware, 2017
- Federal exemptions
- 06b
▶$100KraisedDec 2014 · 1 investors · BiotechnologyRule 506(b)
- Josef SchoellExecutive Officer
- Jeffrey L. IvesDirector
- Joseph W. StaufferExecutive Officer
- Derek ChalmersExecutive Officer, Director
- Michael E. LewisExecutive Officer
- Martin VogelbaumDirector
- Dean SlagelDirector
- Frederique MenzaghiExecutive Officer
- Harrison BainsDirector
- Offering amount
- $100K
- Amount sold
- $100K
- First sale
- Dec 2014
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.
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In the news
Frequently asked questions
- What does Tvardi Therapeutics do?
- Tvardi Therapeutics is a clinical-stage biopharmaceutical company developing oral small molecule STAT3 inhibitors to treat inflammatory and proliferative diseases. Its pipeline includes TTI-101, a direct STAT3 inhibitor in a Phase 2 trial for hepatocellular carcinoma, and TTI-109, a phosphate prodrug of TTI-101.
- Who founded Tvardi Therapeutics?
- Tvardi Therapeutics was founded by David J. Tweardy in 2017.
- Who are Tvardi Therapeutics's investors?
- Tvardi Therapeutics's investors include ShangBay Capital LLC, Solas BioVentures.
- How much funding has Tvardi Therapeutics raised?
- Tvardi Therapeutics has disclosed $78.2M raised across 3 rounds.
- Where is Tvardi Therapeutics headquartered?
- Tvardi Therapeutics is headquartered in Houston, US.









