/Companies

Pathos

Chicago, US · Founded 2020 · 4 known investors

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Pathos applies AI, biological modeling, and a large collection of multimodal oncology patient data to develop cancer drugs and accelerate clinical development. It operates the PathOS platform with engines for asset selection, clinical trial execution, and an oncology foundation model.

Founders & leadership

Pathos was founded in 2020 by Eric Lefkofky, Eric Lefkofsky, and Ryan Fukushima.

ELEric Lefkofky
Eric LefkofkyCo-founder
ELEric Lefkofsky
Eric LefkofskyCo-founderEntrepreneur & Philanthropist
RFRyan Fukushima
Ryan FukushimaCo-founderRyan Fukushima was the first employee at Tempus AI and held leadership roles through its IPO, and currently serves as cofounder and CEO of Pathos, an AI-driven drug development platform focused on oncology therapeutics.
AH
Andrew HeinleinExecutiveInvestor at Lightbank
ADAlex Dolan
Alex DolanGeneral CounselAlex Dolan is an attorney and operations executive with over a decade of experience at healthtech startups in New York. He holds a JD from NYU Law and a BA from the University of Pennsylvania, previously worked at Oscar Health (where he founded the Regulatory Operations function), Formation Bio (where he led digital patient recruitment and site management), and began his career in litigation at Kasowitz Benson.
IHIker Huerga
Iker HuergaChief Executive Officer and Board MemberIker Huerga is a three-time founder with two decades of experience building AI systems for oncology, including roles at Memorial Sloan Kettering, AstraZeneca, and Tempus AI. A cancer survivor, he now serves as Chief Executive Officer of Pathos, which develops cancer drugs using AI and biological modeling.
ESEric Schadt
Eric SchadtChief Science OfficerEric Schadt holds a Ph.D. in biomathematics from UCLA and a B.S. in applied mathematics/computer science from Cal Poly San Luis Obispo. He previously served as Chief Scientific Officer of Sema4 through its public listing and merger agreement, and as Dean for Precision Medicine and Professor of Predictive Health and Computational Biology at the Icahn School of Medicine at Mount Sinai, where he founded the Institute for Genomics and Multiscale Biology and chaired the Department of Genetics and Genomic Sciences.
MDMatt De Silva
Matt De SilvaChief Operating OfficerVenture Partner, Health at Builders VC

Board

AMAmit Mehta
Amit MehtaBoard director
MMMohamad Makhzoumi
Mohamad MakhzoumiBoard directorCo-CEO at New Enterprise Associates (NEA)

Investors · 4

Reported raises · per SEC filings

Form D private placements

$365M disclosed across 3 rounds · 2023–2025

▶$283MraisedMay 2025 · 11 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Ryan FukushimaExecutive Officer, Director
  • Mohamad MakhzoumiDirector
  • Alex DolanExecutive Officer
  • Andrew HeinleinExecutive Officer
  • Tyrell RiversDirector
  • Amit MehtaDirector
  • Eric LefkofkyExecutive Officer, Director
Offering amount
$400M
Amount sold
$283M
First sale
Apr 2025
Incorporated
Corporation, Delaware, 2020
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$62MraisedNov 2024 · 13 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Eric LefkofkyExecutive Officer, Director
  • Amit MehtaDirector
  • Ryan FukushimaExecutive Officer, Director
  • Andrew HeinleinExecutive Officer
  • Mohamad MakhzoumiDirector
  • Alex DolanExecutive Officer
Offering amount
$62M
Amount sold
$62M
First sale
Oct 2024
Incorporated
Corporation, Delaware, 2020
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$20MraisedMar 2023 · 4 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Ryan FukushimaExecutive Officer, Director
  • Eric LefkofskyExecutive Officer, Director
Offering amount
$40M
Amount sold
$20M
First sale
Feb 2023
Incorporated
Corporation, Delaware, 2020
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

Founder mafia

4 people who came through Pathos went on to found or lead other companies.

Frequently asked questions

What does Pathos do?
Pathos applies AI, biological modeling, and a large collection of multimodal oncology patient data to develop cancer drugs and accelerate clinical development. It operates the PathOS platform with engines for asset selection, clinical trial execution, and an oncology foundation model.
Who founded Pathos?
Pathos was founded by Eric Lefkofky, Eric Lefkofsky, Ryan Fukushima in 2020.
Who are Pathos's investors?
Pathos's investors include Cota Capital, Lightbank, Lingotto, New Enterprise Associates (NEA).
How much funding has Pathos raised?
Pathos has disclosed $365M raised across 3 rounds.
Where is Pathos headquartered?
Pathos is headquartered in Chicago, US.