Origin was founded by Yash Rathod, Malhar Bhide, Founder of Siren Biotechnology in 2025.

Who are Origin's investors?

Origin's investors include Glasswing Ventures, Y Combinator, Andreessen Horowitz, Phosphor Capital, Shah Family Office, Topology Ventures.

How much funding has Origin raised?

Origin has disclosed $10B raised across 1 round.

Where is Origin headquartered?

Origin is headquartered in San Francisco, US.

Origin

YC W26

San Francisco, US · Founded 2025 · 4 employees · 6 known investors

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Origin generates spatial molecular maps from patient tumor samples to enable cancer biology research in native tissue context. The platform combines spatial transcriptomics, imaging, and functional perturbation assays on fresh and archived tumors, paired with AI models for drug response prediction and target discovery.

Also known as Origin Bio, Inc.

AI & Machine Learning Biotech Healthtech Medical DevicesUnited States of AmericaAmerica / Canada

Founders & leadership· Y Combinator alumni (W26)

Origin was founded in 2025 by Yash Rathod, Malhar Bhide, and Founder of Siren Biotechnology.

Yash Rathod Co-founder · CEOYash Rathod studied computer science at UIUC and has conducted research in computer vision and reinforcement learning. He is the CEO of Origin.

Malhar Bhide Co-founder · CTOMalhar Bhide studied computer science at UIUC and has worked in ML research roles at Wadhwani AI and Automorphic (YC S23), where he now serves as CTO at Origin.

Founder of Siren BiotechnologyFounder & CEO, Siren Biotechnology · UCSF

Unnamed MIT ProfessorProfessor of Computer Science, MIT · Broad Institute

Dean at Grainger College of Engineering, UIUCDean, Grainger College of Engineering, UIUC

Viraj DoshiFounding Engineerformer

Akshat SinghFounding Engineerformer

Investors · 6

Glasswing Ventureslisted by Glasswing VenturesBoston · $100K – $5M

How we know: Glasswing Ventures's portfolio page · Y Combinator's founder network · Not right? Tell us

Y Combinatorlisted by Y CombinatorSan Francisco · $500K

How we know: the Y Combinator directory · Not right? Tell us

Andreessen HorowitzreportedMenlo Park · $500K – $50M

How we know: Y Combinator's founder network · Not right? Tell us

Phosphor Capitalreported

How we know: Y Combinator's founder network · Not right? Tell us

Shah Family Officereported

How we know: Y Combinator's founder network · Not right? Tell us

Topology VenturesreportedMiami Beach

How we know: Y Combinator's founder network · Not right? Tell us

Funding

SEC filings, press & company announcements

$10B disclosed across 1 round · 2026

$10BraisedJul 2026 · 2 sources
Source ↗

Source: company announcements and press reports — follow each round's link for the claim.

Founder mafia

3 people who came through Origin went on to found or lead other companies.

Yash RathodFounderFounded Origin Malhar BhideFounderFounded Origin Shaamil KarimApplied AIFounded Atlas Discovery

Related companies · 8

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GloGlo14.ai builds software that automates the core operations of e-commerce brands, handling customer acquisition, order fulfillment, and support with minimal human intervention, and uses the platform to operate its own direct-to-consumer business.

bioBIO is the world's largest advocacy association representing biotechnology companies and research institutions across the United States and 30+ other nations. The organization facilitates industry networking through events, conferences, and partnering software while providing cost-savings programs and advocacy services for member companies.

Evolvere BioSciencesEvolvere BioSciences develops antibiotics using computational models and evolutionary data to target pathogenic bacteria while preserving beneficial microbes, designed to resist the development of bacterial resistance.

Form BioForm Bio develops AI-driven software and bioinformatics tools for genetic medicine and genome engineering, enabling faster and safer design of gene therapies, protein engineering, and manufacturing optimization.

Tamarind BioTamarind provides a computational platform for protein and molecular engineering, offering AI and physics-based tools to design antibodies, peptides, enzymes, and small molecules. The platform integrates state-of-the-art published tools like AlphaFold and RFdiffusion through a user-friendly interface for life sciences companies.

Diffuse BioDiffuse designs proteins using AI models trained on experimental data collected through proprietary assays and software, delivering validated AI-designed proteins to partners.

Formation BioFormation Bio develops drugs through partnerships with health systems, academic medical centers, and research sites, focusing on clinical trials in dermatology, rheumatology, and cardiometabolic diseases. The company provides trial management infrastructure, monitoring, technology, and enrollment support to accelerate drug development.

Companies working in the same space as Origin.

Legal entities · 1

corporate structure

Origin Bio, Inc.

In the news

Origin - Safer Cell & Gene Therapies with AIycombinator.com · Feb 2026

Frequently asked questions

What does Origin do?: Origin generates spatial molecular maps from patient tumor samples to enable cancer biology research in native tissue context. The platform combines spatial transcriptomics, imaging, and functional perturbation assays on fresh and archived tumors, paired with AI models for drug response prediction and target discovery.
Who founded Origin?: Origin was founded by Yash Rathod, Malhar Bhide, Founder of Siren Biotechnology in 2025.
Who are Origin's investors?: Origin's investors include Glasswing Ventures, Y Combinator, Andreessen Horowitz, Phosphor Capital, Shah Family Office, Topology Ventures.
How much funding has Origin raised?: Origin has disclosed $10B raised across 1 round.
Where is Origin headquartered?: Origin is headquartered in San Francisco, US.