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Opalite Health

YC W26

San Francisco, US · Founded 2025 · 3 employees · Hiring · 13 known investors

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Opalite builds language interpretation technology for healthcare, enabling real-time communication between physicians and patients across language barriers. The platform serves clinicians and care teams to improve patient safety and diagnostic accuracy.

Also known as Calliope AI Inc. · Calliope

AI & Machine LearningDigital HealthHealthtechUnited States of AmericaAmerica / CanadaPartly Remote

Founders & leadership· Y Combinator alumni (W26)

Opalite Health was founded in 2025 by Cathleen Kuo and Alex Mehregan.

CKCathleen Kuo
Cathleen KuoCo-Founder, CEOCathleen Kuo is a physician and AI healthcare researcher with over 200 publications who leads Opalite Health, which develops healthcare technology.
AMAlex Mehregan
Alex MehreganCo-founder, CTOAlex Mehregan is Chief Technology Officer at Opalite Health and previously worked as an engineer at Apple on Siri and system experience projects. He holds a degree in electrical engineering and computer science from UC Berkeley.

Investors · 13

Sterling Roadlisted by Sterling RoadSan Francisco · $25K – $150K

How we know: Sterling Road's portfolio page · Y Combinator's founder network · Not right? Tell us

Y Combinatorlisted by Y CombinatorSan Francisco · $500K

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007 Venture Partnersreported

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Blast.Clubreported$5.5M

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Coyote VenturesreportedSan Francisco

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Dent CapitalreportedMenlo Park

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Ingenerate Labsreported$10K – $200K

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Multifaceted CapitalreportedSeattle

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MyAsiaVCreportedSeattle

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RobinhoodreportedMenlo Park

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Seraph GroupreportedMilton · $50K – $2M

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Tabula Rasa Venturesreported$50K – $1M

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Related companies · 2

Vytalize HealthVytalize Health provides clinical decision support and remote care management services for physicians and practices. Its offerings include a clinical decision tool delivering evidence-based recommendations at the point of care and a suite of interdisciplinary remote care programs.
Qualified HealthQualified Health AI provides AI infrastructure and governance solutions for health systems to deploy generative AI safely and deliver measurable value across clinical, operational, and financial workflows. The platform is built by healthcare and AI leaders to enable enterprise-wide AI adoption with proper oversight and clinical alignment.

Companies working in the same space as Opalite Health.

Legal entities · 1

corporate structure
Calliope AI Inc.

In the news

16 of the most interesting startups from YC W26 Demo Daytechcrunch.com · Mar 2026Opalite Health: Helping Healthcare Providers Speak Any Languageycombinator.com · Jan 2026Opalite Health Funding | Complete Analysis | Extruct AIextruct.ai

Frequently asked questions

What does Opalite Health do?
Opalite builds language interpretation technology for healthcare, enabling real-time communication between physicians and patients across language barriers. The platform serves clinicians and care teams to improve patient safety and diagnostic accuracy.
Who founded Opalite Health?
Opalite Health was founded by Cathleen Kuo, Alex Mehregan in 2025.
Who are Opalite Health's investors?
Opalite Health's investors include Rebel Fund, Sterling Road, Y Combinator, 007 Venture Partners, Blast.Club, Coyote Ventures, Dent Capital, Ingenerate Labs and 5 more.
Where is Opalite Health headquartered?
Opalite Health is headquartered in San Francisco, US.