Nucleo
YC F25Founded 2025 · 2 employees · 4 known investors
Nucleo automates CT scan analysis for oncology care, providing AI-powered tools for tumor lesion sizing, body composition assessment, and lesion classification to support clinical workflows in hospitals.
Founders & leadership· Y Combinator alumni (F25)
Nucleo was founded in 2025 by Angelica Iacovelli and Luca Pegolotti.
AI
Angelica Iacovelliin𝕏CEO, Co-founderShe previously conducted research at Stanford University on cardiovascular modeling and fluid dynamics simulation, with contributions to NVIDIA's scientific computing libraries. She holds a BS and MS in Mathematical Engineering from Politecnico di Milano and completed a research exchange at IIT Madras.
LP
Luca PegolottiinCo-founder & CTOLuca Pegolotti holds a BSc from Politecnico di Milano and an MSc and PhD from EPFL, with research experience at Stanford School of Medicine. He previously worked on physics-informed machine learning at Apple Health AI, focusing on computational methods and AI applications in healthcare.
Investors · 4
In the news
Frequently asked questions
- What does Nucleo do?
- Nucleo automates CT scan analysis for oncology care, providing AI-powered tools for tumor lesion sizing, body composition assessment, and lesion classification to support clinical workflows in hospitals.
- Who founded Nucleo?
- Nucleo was founded by Angelica Iacovelli, Luca Pegolotti in 2025.
- Who are Nucleo's investors?
- Nucleo's investors include Y Combinator, 6th Man Ventures, Bain Capital Crypto, Lombardstreet Ventures.


