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Nucleo

YC F25

San Francisco, US · Founded 2025 · 2 employees · 4 known investors

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Nucleo automates CT scan analysis for oncology care, providing AI-powered tools for tumor lesion sizing, body composition assessment, and lesion classification to support clinical workflows in hospitals.

Also known as Nucleo Research, Inc.

AI & Machine LearningHealthtechMedical DevicesUnited States of AmericaAmerica / CanadaPartly Remote

Founders & leadership· Y Combinator alumni (F25)

Nucleo was founded in 2025 by Angelica Iacovelli and Luca Pegolotti.

AIAngelica Iacovelli
Angelica IacovelliCEO, Co-founderShe previously conducted research at Stanford University on cardiovascular modeling and fluid dynamics simulation, with contributions to NVIDIA's scientific computing libraries. She holds a BS and MS in Mathematical Engineering from Politecnico di Milano and completed a research exchange at IIT Madras.
LPLuca Pegolotti
Luca PegolottiCo-founder & CTOLuca Pegolotti holds a BSc from Politecnico di Milano and an MSc and PhD from EPFL, with research experience at Stanford School of Medicine. He previously worked on physics-informed machine learning at Apple Health AI, focusing on computational methods and AI applications in healthcare.
AI
Angelica Iacovelli Luca PegolottiFounder

Investors · 4

6th Man VenturesreportedNew York · $2M – $5M

How we know: funding news · Not right? Tell us

Bain Capital CryptoreportedSan Francisco

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Lombardstreet VenturesreportedWoodside · $500K

How we know: the VCSheet dataset · open dataset · 5k.vc investor directory · Not right? Tell us

Funding

SEC filings, press & company announcements

Source: company announcements and press reports — follow each round's link for the claim.

Legal entities · 1

corporate structure
Nucleo Research, Inc.

In the news

Nucleo: Automated Cancer Diagnosticsycombinator.com · Nov 2025

Frequently asked questions

What does Nucleo do?
Nucleo automates CT scan analysis for oncology care, providing AI-powered tools for tumor lesion sizing, body composition assessment, and lesion classification to support clinical workflows in hospitals.
Who founded Nucleo?
Nucleo was founded by Angelica Iacovelli, Luca Pegolotti in 2025.
Who are Nucleo's investors?
Nucleo's investors include Y Combinator, 6th Man Ventures, Bain Capital Crypto, Lombardstreet Ventures.
Where is Nucleo headquartered?
Nucleo is headquartered in San Francisco, US.