/Companies

Kriya Therapeutics

Morrisville, US · Founded 2019 · Delaware corporation · 202 employees on LinkedIn · 17 known investors

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Kriya Therapeutics is a biopharmaceutical company that develops and manufactures one-time gene therapies aimed at treating prevalent chronic diseases. It uses AAV-mediated gene therapy approaches across metabolic, neurodegenerative, and other disease areas.

Also known as Kriya

Founders & leadership

Kriya Therapeutics was founded in 2019 by Roger Jeffs, Fraser Wright, and Shankar Ramaswamy.

RJRoger Jeffs
Roger JeffsCo-Founder & Vice ChairmanRoger Jeffs is Vice Chairman and co-founder of Kriya Therapeutics and CEO of Liquidia Corporation, a biopharmaceutical company focused on pulmonary hypertension treatments. He previously spent 18 years at United Therapeutics Corporation, where he served as President and co-CEO and oversaw clinical development and regulatory approval of six rare disease products, and earlier held clinical development roles at Amgen and Burroughs Wellcome. He holds a B.S. in chemistry from Duke University and a Ph.D. in pharmacology from the University of North Carolina School of Medicine.
FWFraser Wright
Fraser WrightScientific Co-Founder and Chief Gene Therapy OfficerHe co-founded Spark Therapeutics, serving as its Chief Technology Officer and advisor, and later was Chief Technology Officer at Axovant Gene Therapies. His academic appointments include professor of pathology and laboratory medicine at the University of Pennsylvania School of Medicine and professor of pediatrics in Stanford's Center for Definitive and Curative Medicine; he also runs Wright Biologics Consulting.
SRShankar Ramaswamy
Shankar RamaswamyCo-Founder and Chief Executive OfficerShankar Ramaswamy, M.D., is co-founder, chairman, and CEO of Kriya Therapeutics, a biopharmaceutical company developing and manufacturing one-time gene therapies for chronic diseases. He was previously part of the early team at Roivant Sciences and led corporate development at its subsidiary Axovant Sciences through its 2015 IPO; he holds a medical degree from Brown University and an undergraduate degree in economics from Harvard University.
MSMichele Stone
Michele StoneChief Scientific OfficerMichele Stone is Chief Scientific Officer at Kriya Therapeutics, a developer of AAV-mediated gene therapies for chronic diseases. She brings extensive biotech R&D experience spanning vaccine, immunotherapy, gene therapy, and small molecule programs, with leadership in business development, product strategy, and bioanalytical functions.
KEKatherine Eade
Katherine EadeChief Legal Officer
BPBritt Petty
Britt PettyPresident Manufacturing and Technical Operations
SMSachiyo Minegishi
Sachiyo MinegishiChief Financial Officer
GDGreg Di Russo
Greg Di RussoChief Medical OfficerHe previously held leadership roles in clinical development at Pfizer, including heading late-stage hematology programs with expertise in gene therapy, bleeding disorders, and sickle cell disease, and has clinical practice experience in cardiac surgery and transplantation.
BFBrian Furmanski
Brian FurmanskiChief Development Officer
MCMark Chen
Mark ChenChief Operating Officer
IOIlan Oren
Ilan OrenNamed on SEC filing
DC
Daniel ChenNamed on SEC filing

Investors · 17

Also in the syndicate · 7

Asia AlphaCAM CapitalDexcel PharmaHongkouQVTThe T1D Fund: A Breakthrough T1D VentureWoodline Partners LP

Reported raises · per SEC filings

Form D private placements

$870.3M disclosed across 4 of 5 rounds · 2020–2025

▶$320.8MraisedSep 2025 · 10 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Neelaksh VarshneyDirector
  • Michele StoneExecutive Officer
  • Ilan OrenDirector
  • Saira RamasastryDirector
  • Ryan GallagherDirector
  • Keith ManchesterDirector
  • Katherine EadeExecutive Officer
  • James MomtazeeDirector
  • Akshay RaiDirector
  • Shankar RamaswamyExecutive Officer, Director
  • Curt HerbertsExecutive Officer
  • Britt PettyExecutive Officer
  • Roger JeffsDirector
  • Brian FurmanskiExecutive Officer
  • Trit GargDirector
Offering amount
$320.8M
Amount sold
$320.8M
First sale
Jul 2025
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$361.8MraisedJul 2023 · 29 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • James MomtazeeDirector
  • Neelaksh VarshneyDirector
  • Roger JeffsDirector
  • Dana JohnsonExecutive Officer
  • Britt PettyExecutive Officer
  • Trit GargDirector
  • Michele StoneExecutive Officer
  • Curt HerbertsExecutive Officer
  • Keith ManchesterDirector
  • Saira RamasastryDirector
  • Shankar RamaswamyExecutive Officer, Director
  • Ilan OrenDirector
Offering amount
$432M
Amount sold
$361.8M
First sale
May 2022
Incorporated
Corporation, Delaware, 2019
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$100MraisedJul 2021 · 36 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Daniel ChenExecutive Officer
  • Ilan OrenDirector
  • Keith ManchesterDirector
  • Saira RamasastryDirector
  • Roger JeffsDirector
  • C.R. SincockDirector
  • Dana JohnsonExecutive Officer
  • James MomtazeeDirector
  • Shankar RamaswamyExecutive Officer, Director
Offering amount
$100M
Amount sold
$100M
First sale
Jun 2021
Incorporated
Corporation, Delaware, 2019
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$87.6MraisedAug 2020 · 21 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Ilan OrenDirector
  • Keith ManchesterDirector
  • Roger JeffsDirector
  • C.R. SincockDirector
  • Shankar RamaswamyExecutive Officer, Director
Offering amount
$87.6M
Amount sold
$87.6M
First sale
May 2020
Incorporated
Corporation, Delaware, 2019
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

Company profile

researched Aug 2026

Kriya Therapeutics is a biopharmaceutical company developing what it describes as "durable medicines" — treatments designed to be administered once and provide a lasting therapeutic effect — for chronic diseases. The company positions itself as an integrated organization in which research, development, and manufacturing operate together, incorporating production considerations into early-stage drug discovery rather than relying on outsourced or off-the-shelf processes.

Kriya's disclosed investigational pipeline spans five named programs across ophthalmic, endocrine, metabolic, hepatic, and neurological indications: KRIYA.825 for geographic atrophy, KRIYA.586 for thyroid eye disease, KRIYA.288 for type 1 diabetes, KRIYA.497 for steatotic liver disease, and KRIYA.748 for trigeminal neuralgia. The company has also reported preclinical work on an AAV-FGF21 gene therapy studied in aged mice. All of Kriya's medicines are investigational and have not been approved as safe or effective by any regulatory health authority.

Business model

Kriya develops proprietary one-time therapeutic candidates in-house and operates its own manufacturing capability, describing an integrated "product engine" that links research, development, and production rather than depending on external commodity processes.

Traction

The company has disclosed five named investigational programs. In June 2026 it announced selection for the FDA PreCheck Pilot Program, and in August 2026 it announced publication of preclinical data on an AAV-FGF21 gene therapy that extended health span and lifespan in aged mice.

Latest developments

In June 2026 Kriya announced it was selected for the FDA PreCheck Pilot Program, and in August 2026 it announced the publication of preclinical data showing that an AAV-FGF21 gene therapy extended health span and lifespan in aged mice.

▸Full profile — market position, technology, go-to-market, geography, risks & controversies

Market position

Kriya describes its portfolio as one of the industry's broadest collections of durable medicines, targeting chronic diseases that are conventionally treated with ongoing, repeat-administration therapies.

Kriya emphasizes vertical integration of discovery, development, and manufacturing; the incorporation of manufacturability into early drug design; and the use of its HOPSON structured manufacturing dataset together with computational and AI tools to inform successive programs.

Technology

Kriya's approach centers on durable, one-time-administration medicines, including AAV-based gene therapy candidates. The company states it has assembled a structured manufacturing dataset called HOPSON and applies artificial intelligence and applied computational tools to data generated from experiments and manufacturing runs, with the aim of improving process efficiency as more data accumulates. Each program is described as being engineered on the same underlying system so that development learnings carry across the portfolio.

Go-to-market

Patients with chronic diseases, addressed through indications including geographic atrophy, thyroid eye disease, type 1 diabetes, steatotic liver disease, and trigeminal neuralgia.

Geography

Kriya operates a campus in Research Triangle Park, North Carolina, housing scientists, engineers, and operators alongside its manufacturing activities.

Risks & controversies

All of Kriya's candidates are investigational and have not received regulatory approval as safe or effective, so the pipeline remains subject to clinical and regulatory outcomes.

Compiled by commissioned research from 1 cited public sources — announcements, filings, and press listed under research sources below.

Key figures

latest reported
Disclosed investigational programsJan 20265 programs

Company-reported or press-reported figures, each dated to when it was claimed — not independently audited.

Founder mafia

2 people who came through Kriya Therapeutics went on to found or lead other companies.

Related companies · 2

Companies working in the same space as Kriya Therapeutics.

Timeline · 2

launches, deals, and filings
Aug 2026
Publication of preclinical data on AAV-FGF21 gene therapy in aged mice

Kriya announced the publication of preclinical data reporting that an AAV-FGF21 gene therapy extended health span and lifespan in aged mice.

source ↗

Jun 2026
Selected for FDA PreCheck Pilot Program

Kriya announced it had been selected for the U.S. FDA's PreCheck Pilot Program.

source ↗

Dated company events from announcements, filings, and press; legal rows summarize public dockets and regulator releases.

Legal entities · 1

corporate structure
Kriya TherapeuticsDelaware

▸Research sources · 1

primary sources listed

1 public sources were cited for this profile; the first-party ones are listed here.

Frequently asked questions

What does Kriya Therapeutics do?
Kriya Therapeutics develops one-time "durable medicines", including AAV gene therapies, for chronic diseases.
Who founded Kriya Therapeutics?
Kriya Therapeutics was founded by Roger Jeffs, Fraser Wright, Shankar Ramaswamy in 2019.
Who are Kriya Therapeutics's investors?
Kriya Therapeutics's investors include Patient Square Capital, Premji Invest, Alumni Ventures, Amplo Ventures, Anjost, Bluebird Ventures, Foresite Capital, Holland Capital and 2 more.
How much funding has Kriya Therapeutics raised?
Kriya Therapeutics has disclosed $870.3M raised across 4 of its 5 known rounds.
Where is Kriya Therapeutics headquartered?
Kriya Therapeutics is headquartered in Morrisville, US.