Empirical Bio
Entrepreneur First '24London, GB · Founded 2024 · 2 known investors
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Empirical Bio builds machine learning software that predicts and optimizes the structure of enzymes and other biomolecules. Biotech research teams use it to narrow down candidates computationally before moving to the bench, which reduces the number of laboratory testing cycles required.
Also known as Empirical
Founders & leadership
Empirical Bio was founded in 2024 by Jamie Weigold.

Investors · 2
Company profile
researched Aug 2026Empirical Bio is a London-based company founded in 2024 that develops machine learning software for predicting and optimizing the structures of enzymes and other biomolecules, with the aim of letting biotech research teams shortlist candidates computationally and reduce the number of laboratory testing cycles required. The company appears in the Entrepreneurs First portfolio directory, which indexes companies by location, industry, founding year and funding stage.
As of the material reviewed, the company's public web presence is minimal: its website at empirical.sh consists of a placeholder page marked "Launching Soon" with an email sign-up form for updates, carrying a 2024 copyright notice. No product documentation, customer references, pricing, team page or funding disclosures are available on the public site.
Note on name twins: several sources retrieved under similar names refer to Empirical Bioscience, Inc., a US developer and manufacturer of enzymes, proteins and reagents acquired by Fortis Life Sciences. That is a distinct company and its facts are not included in this profile.
Traction
No traction metrics, customers, partnerships or funding amounts are disclosed in the available sources.
Latest developments
The company's website was, at the time of retrieval, a pre-launch placeholder stating "Launching Soon" and collecting email addresses for future updates, indicating the product had not yet been publicly released.
▸Full profile — geography
Geography
The company is associated with London, United Kingdom; the Entrepreneurs First portfolio directory from which the company is listed segments companies across locations including London.
Compiled by commissioned research from 5 cited public sources — announcements, filings, and press listed under research sources below.
Companies House · registry record
View on Companies House ↗- Registered name
- EMPIRICAL BIO LTD
- Company number
- 16181256
- Status
- Active
- Company type
- Private limited company
- Incorporated
- 13 Jan 2025
- Registered office
- 86-90 Paul Street, London, EC2A 4NE
- Nature of business (SIC)
- 58290 — Other software publishing62012 — Business and domestic software development
- Accounts
- last made up to 31 Dec 2025 · next due 30 Sept 2027
- Confirmation statement
- last made up to 12 Jan 2026 · next due 26 Jan 2027
Current officers · 1
- Jamie Weigold — director, appointed 13 Jan 2025
Source: Companies House public register · retrieved 30 Aug 2026. Contains public sector information licensed under the Open Government Licence v3.0.
▸Research sources · 5
primary sources listed
- Empirical Bioempirical.sh · web
5 public sources were cited for this profile; the first-party ones are listed here.
Frequently asked questions
- What does Empirical Bio do?
- London-based Entrepreneurs First-backed startup building ML software to predict and optimize enzyme and biomolecule structures.
- Who founded Empirical Bio?
- Empirical Bio was founded by Jamie Weigold in 2024.
- Who are Empirical Bio's investors?
- Empirical Bio's investors include Entrepreneur First, Transpose Platform Management.
- Where is Empirical Bio headquartered?
- Empirical Bio is headquartered in London, GB.



