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Dialectic Therapeutics

San Antonio, US · Founded 2018 · Delaware corporation

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Dialectic Therapeutics is a clinical-stage biotechnology company developing anti-cancer drugs using its Antiapoptotic Protein Targeted Degradation (APTaD) platform, which induces cancer cells to degrade proteins such as BCL-XL. Its lead candidate, DT2216, is in Phase 1/2 trials for fibrolamellar carcinoma and platinum-resistant ovarian cancer.

Founders & leadership

Dialectic Therapeutics was founded in 2018 by Daohong Zhou, Guangrong Zheng, and John D. Harkey Jr., JD, MBA.

DZ
Daohong ZhouBoard Member & Scientific Co-founder
GZGuangrong Zheng
Guangrong ZhengDirector of Medicinal Chemistry & Scientific Co-founder
JDJohn D. Harkey Jr., JD, MBA
John D. Harkey Jr., JD, MBAExecutive Chairman & Co-founder
DG
David GenecovPresident & CEO, Co-founder, Board Member (In Memoriam)
JD
John D. HarkeyNamed on SEC filing
RH
Robert HromasBoard Member & Scientific Co-founder

Funding

SEC filings, press & company announcements

$8.8M disclosed across 3 of 4 rounds · 2018–2020

▶$6.3MraisedFeb 2021 · 27 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • David GenecovExecutive Officer, Director
  • John D. HarkeyDirector
  • Daohong ZhouDirector
  • Joshua SillsExecutive Officer
  • Robert HromasDirector
Offering amount
$6.3M
Amount sold
$6.3M
Minimum investment
$50K
Proceeds to insiders
$100K
First sale
Dec 2020
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$500KraisedOct 2020 · 12 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • John D. HarkeyDirector
  • David GenecovExecutive Officer, Director
  • Daohong ZhouDirector
  • Robert HromasDirector
Offering amount
$500K
Amount sold
$500K
Minimum investment
$2.5K
First sale
Sep 2020
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$2MraisedNov 2018 · 2 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • David GenecovDirector
  • John D. HarkeyDirector
  • Daohong ZhouExecutive Officer, Director
  • Robert HromasExecutive Officer, Director
Offering amount
$7M
Amount sold
$2M
First sale
Nov 2018
Incorporated
Corporation, Delaware, 2018
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

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Frequently asked questions

What does Dialectic Therapeutics do?
Dialectic Therapeutics is a clinical-stage biotechnology company developing anti-cancer drugs using its Antiapoptotic Protein Targeted Degradation (APTaD) platform, which induces cancer cells to degrade proteins such as BCL-XL. Its lead candidate, DT2216, is in Phase 1/2 trials for fibrolamellar carcinoma and platinum-resistant ovarian cancer.
Who founded Dialectic Therapeutics?
Dialectic Therapeutics was founded by Daohong Zhou, Guangrong Zheng, John D. Harkey Jr., JD, MBA in 2018.
How much funding has Dialectic Therapeutics raised?
Dialectic Therapeutics has disclosed $8.8M raised across 3 of its 4 known rounds.
Where is Dialectic Therapeutics headquartered?
Dialectic Therapeutics is headquartered in San Antonio, US.